Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates.
نویسندگان
چکیده
The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic Cu for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.
منابع مشابه
Copper-catalyzed decarboxylative trifluoromethylation of allylic bromodifluoroacetates.
The development of new synthetic fluorination reactions has important implications in medicinal, agricultural, and materials chemistries. Given the prevalence and accessibility of alcohols, methods to convert alcohols to trifluoromethanes are desirable. However, this transformation typically requires four-step processes, specialty chemicals, and/or stoichiometric metals to access the trifluorom...
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متن کاملProgress in copper-catalyzed trifluoromethylation
The introduction of trifluoromethyl groups into organic molecules has attracted great attention in the past five years. In this review, we describe the recent efforts in the development of trifluoromethylation via copper catalysis using nucleophilic, electrophilic or radical trifluoromethylation reagents.
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ورودعنوان ژورنال:
- Synthesis
دوره 46 14 شماره
صفحات -
تاریخ انتشار 2014